Ogtt gestational diabetes

Beavatkozás neve: Metformin Hydrochloride Leírás: Women randomised to the metformin group will receive metformin mg once daily, with the dose titrated upwards every 2 days over 10 days increasing to a maximum of mg Metformin daily 5 tablets or maximum tolerated dose, in addition to usual care exercise ogtt gestational diabetes MNTand taken until delivery.

Karcsoport címke: Treatment Beavatkozás neve: Placebo Leírás: Women randomised to the placebo group will receive 1 placebo tablet once daily, with the dose titrated upwards every 2 days over 10 days increasing to a maximum of five placebo tablets daily, in addition to usual care exercise and MNTand taken until delivery. Willing and able to provide written informed consent 2.

Women aged 3. Singleton pregnancy as determined by scan 5.

Resident in the locality and intending to deliver within the trial site Exclusion Criteria: 1. Participants who have an established diagnosis of diabetes Type 1, Type 2, Monogenic or secondary 2. Multiple pregnancies twins, triplets etc.

Known intolerance to metformin 5. Major congenital malformations or an abnormally deemed unsuitable for metformin ogtt gestational diabetes the site PI or attending consultant 7. Known small for gestational age Small for gestational age SGA refers to foetal growth less than the 10th percentile RCOG,or if foetal growth is deemed unsatisfactory by the treating obstetrician 8.

Known gestational hypertension or pre-eclampsia or ruptured membranes 9. Participants who have a history of drug or alcohol use that, in the opinion of the investigator, would interfere with adherence to study requirements Participants with significant gastrointestinal problems such as severe vomiting, Crohn's disease or colitis which will inadvertently affect absorption of the study drug Participants with congestive heart failure or history of congestive heart failure Participants with serious mental illness which would affect adherence to study medication or compliance with study protocol in the opinion of the investigator Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption Nem:.